On April 16 2019, Madonna announced that the first single from her forthcoming album, Madame X, would be released on Wednesday April 17 (at 9am in Los Angeles, 12pm in New York City and 5pm London time). The lead single, Medellin, features Colombian singer/songwriter Maluma (Juan Luis Londoño Arias).

“Madame ❌ is a cha-cha instructor…………….. #nunoxico
1, 2…2morrow #Medellin ft MALUMA 9AM Los Angeles / 12PM NYC / 5PM London” – Madonna