On August 5 2008, Madonna’s Give It 2 Me was released as a CD maxi-single by Warner Bros. Records in the U.S. It included amazing club remixes by Eddie Amador, Paul Oakenfold, Fedde Le Grand, Tong & Spoon, Jody den Broeder, and a ragga mix by Sly & Robbie.

The single was also issued in the U.S. as a double-vinyl 12-inch set, a 12-inch vinyl picture disc and as a double-vinyl 7-inch set coupled with her previous single, 4 Minutes. Though no Canadian pressings of the single were issued, the U.S. CD maxi-single was distributed to Canadian retailers with a Warner Music Canada special import sticker.

Give It 2 Me was the second single from Hard Candy. It was written by Madonna & Pharrell Williams with production by Madonna & The Neptunes. An early demo version of the song with alternate lyrics, titled Infinity, would eventually surface online.